| October 20, 2021 | ||
| Homeboyz | 15:00 | Tusker |
| October 23, 2021 | ||
| Ulinzi Stars | 13:00 | Gor Mahia |
| October 24, 2021 | ||
| Police | 15:00 | Tusker |
| October 29, 2021 | ||
| Leopards | 13:00 | Ulinzi Stars |
| October 30, 2021 | ||
| Posta Rangers | 13:00 | Nairobi City Stars |
| Gor Mahia | 13:00 | Sofapaka |
| Tusker | 15:00 | Wazito |
| Bidco United | 15:00 | Nzoia Sugar |
| KCB | 15:00 | Police |
| October 31, 2021 | ||
| Mathare United | 14:00 | Kariobangi Sharks |
| Vihiga Bullets | 14:00 | Homeboyz |
| Bandari | 16:00 | Talanta |
| November 5, 2021 | ||
| Wazito | 14:00 | KCB |
| November 6, 2021 | ||
| Kariobangi Sharks | 14:00 | Tusker |
| Police | 15:00 | Gor Mahia |
| Mathare United | 16:00 | Bidco United |
| Nzoia Sugar | 16:00 | Posta Rangers |
| Nairobi City Stars | 16:00 | Vihiga Bullets |
