| October 15, 2021 | ||
| Kariobangi Sharks | 13:00 | Gor Mahia |
| October 16, 2021 | ||
| Tusker | 15:00 | Talanta |
| October 20, 2021 | ||
| Vihiga Bullets | 13:00 | Kariobangi Sharks |
| Police | 13:15 | Nzoia Sugar |
| Leopards | 15:00 | Gor Mahia |
| Bandari | 15:00 | Posta Rangers |
| Talanta | 15:00 | KCB |
| Ulinzi Stars | 15:00 | Bidco United |
| Homeboyz | 15:00 | Tusker |
| Sofapaka | 15:00 | Mathare United |
| October 21, 2021 | ||
| Nairobi City Stars | 15:00 | Wazito |
| October 23, 2021 | ||
| Ulinzi Stars | 13:00 | Gor Mahia |
| Sofapaka | 15:00 | KCB |
| October 24, 2021 | ||
| Kariobangi Sharks | 13:00 | Wazito |
| Police | 15:00 | Tusker |
| Bandari | 15:00 | Leopards |
| Homeboyz | 15:00 | Posta Rangers |
| Talanta | 15:00 | Vihiga Bullets |
| Nzoia Sugar | 15:00 | Mathare United |
| Nairobi City Stars | 15:00 | Bidco United |
